Fatty acids and their intermediates and derivatives have been recognized as crucial mediators of brain health. Consequently, disturbances in brain fatty acid metabolism are highly implicated in different aspects of neuronal dysfunction.
The thematic area of FAT4BRAIN is focused on the pivotal and common role of mitochondria-related fatty acid metabolism for the development of neurological disorders, a topic of highest biomedical and societal concern. The concerted research activities aim at deciphering novel mechanisms and developing new treatment strategies against these devastating diseases.
FAT4BRAIN Online workshopsFAT4BRAIN held 2 online workshops in June
June was busy month for our FAT4BRAIN project - 2 workshops took place online
On June 8th WP1 Workshop on central regulatory mechanisms of energy metabolism hosted by Uppsala University team took place. During the workshop the lecture on latest findings and up-to-date technologies on the energy metabolism research in brain were given by the researchers from Uppsala University, Eberhard Karls Universitaet Tuebingen and invited speakers. 45 participants of workshop found out what are metabolic abnormalities in major depressive disorders, how LEAP2 regulates ghrelin system, and why Drosophila is useful modle to study energy metabolism in CNS.
On June 18th 2nd workshop in series of workshops on career development “How to become a successful researcher” took place. The workshop was dedicated to Innovation and how to develop Innovation thinking using NABC model, as well as Teamwork in Project Management and what are critical points in teamwork development and how to deal with it.
Virtual training on high-resolution respirometryTraining in high-resolution respirometry (HRR) for the assessment of mitochondrial energetics took place online on March 3-4, 2021
During training young investigators performed instrument set-up and experiment with permeabilized cells on O2ks under supervision provided online by Oroboros Instruments exprienced researcher.
Training also involved a basal education in respiratory concepts and approaches and specific training in the use of substrate-uncoupler-inhibitor-titration (SUIT) protocols for the evaluation of respiratory parameters in intact and permeabilised cells with focus on fatty acid metabolism assessment. Based on new protocols recently developed by the science team at Oroboros Intruments, the researcher learned how to apply HRFR in studies on cell culture, as well as preclinical and clinical samples.