• Sci area

    Fatty acids and their intermediates and derivatives have been recognized as crucial mediators of brain health. Consequently, disturbances in brain fatty acid metabolism are highly implicated in different aspects of neuronal dysfunction.

    The thematic area of FAT4BRAIN is focused on the pivotal and common role of mitochondria-related fatty acid metabolism for the development of neurological disorders, a topic of highest biomedical and societal concern. The concerted research activities aim at deciphering novel mechanisms and developing new treatment strategies against these devastating diseases.

  • News

    • Early-stage researchers visit LIOS for Summer school in functional pharmacology

      Summer school in functional pharmacology to study the role of fatty acid metabolism in the brain, June 6-10, 2022

      In the beginning of June Latvian Institute of Organic Synthesis hosted a Summer school in functional pharmacology mainly dedicated to early-stage researchers. The Summer school started off with an interactive board game on drug development “TEST TUBES TO TABLETS” led by Keith J Williams from KW Drug Development. Speakers from LIOS, Prof. M.Dambrova, Dr. O. Pugovics, Prof. K. Jaudzems and Dr. E. Liepinsh shared their experience in drug discovery projects and gave lectures on the applicable methods and models that are developed and widely used at LIOS. Prof. H. Schiöth from Uppsala University gave a comprehensive talk on drug target classes, and a specific session was held with him to discuss how to prepare for a job interview. Participants of the Summer school also had the opportunity to share their work in a poster session and short oral presentations, as well as gain new experience in hands-on workshops on histology, behavioural studies, bioanalytical methods, statistics, and data visualization. Overall, the participants of the Summer school enjoyed gaining new knowledge, valuable discussions and networking throughout the event and were happy to meet face-to-face.

    • FAT4BRAIN partners participate in a workshop organized by Oroboros Instruments

      FAT4BRAIN Workshop on mitochondrial function in CNS-related applications: from pre-clinical to clinical studies, May 2-3, 2022

      In the beginning of May 2022, FAT4BRAIN partners participated in a workshop, which was organised by Oroboros Innstruments in Innsbruck, Austria.Prof. M.Dambrova (LIOS, Latvia), Dr. I.Fontana (Karolinska Institute, Sweden), Assoc. prof. J. Ehinger (Lund University, Sweden), Assoc. prof. R.K.Jentoft Olsen (Aarhus University, Denmark), Assoc. prof. N.Moisoi (De Montfort University, United Kingdom) and Assoc. prof. T.Komlodi (Semmelweis University, Hungary) gave lectures on the role of mitochondria in a various physiological and pathological processes in the preclinical and clinical samples. During the workshop a dedicated session was held to discuss FAO-Mito-CNS functionality assessment platform. Discussion was focussed on targeted analysis in brain diseases, disease-specific biomarkers, blood based approaches and opportunities on how to get more data out of single sample, as well as some specific cellular models and stress conditions were evaluated. Therefore, new opportunities and ideas for the fatty-acid oxidation measurements were suggested and will be included in the Bioblast platform. FAT4BRAIN partners also received a face-to-face demonstration of NextGen-O2k and its capabilities and visited Oroboros Innstruments laboratories. Participants enjoyed this workshop and were very happy to meet each other on-site in Innsbruck and discuss possible collaborations in the future.